Effect of Jujuboside A on Brain Ischemia / Reperfusion Injury Via Expression of Antiapoptotic Gene

Background: Some studies highlighted the role of Jujuboside A as a potent antioxidant on ischemic neurons. However, definitive effect this substance change in expression neuroprotective genes has not been clearly identified. Therefore, study aimed to investigate effects proliferation-inducing and cell count enhancement hippocampus after induction transient global ischemia/reperfusion. Materials Methods: This experimental was performed 24 male Wistar rats four groups control, ischemia, vehicle, A. Three days animals removed isolated from brain tissue. In order results intervention, nuclear factor-κB (NF-κB), nerve growth factor (NGF), Brain-derived neurotrophic (BDNF) were determined using real-time polymerase chain reaction. Results: The showed that NGF significantly higher group than (P<0.05). Moreover, BDNF increased compared group. NFκB lower control groups, but these changes significant (P>0.05). Conclusion: can increase by promoting protective